The richest, most capable builder alive has maximal access to everything money can buy, extraordinary IQ, and omnipotent AI. That makes him the cleanest natural experiment in human longevity.
It appears that we are not yet in touch with (or at least, not yet effectively addressing) the deepest root cause(s) of age-related decline, and too focused on downstream damage. The Whack-a-mole approach, which will be increasingly challenged as a progressively increasing number of moles pop up, is essentially doomed to incremental improvement and ultimate failure. I suspect that even massive/progressive organ replacement will suffer from this effect, as each fresh organ will suffer accelerated aging by the progressively degrading plasma constitution. I'd greatly appreciate your take on this perspective.
A key insight from longevity science is that lifespan and healthspan are not the same. Genetics and access to care matter, but daily behaviors such as sleep, fitness, metabolic health, and stress management remain some of the strongest modifiable predictors of long-term cognitive and physical performance. Sustainable output starts with sustainable biology.
Fantastic read. It does seem enough people are spending their lives and resources to find ways to extend lives, yet, nothing has been truly successful in my wee little purview. I will go so far as to print this out to read more diligently.
Why repair aging bodies when you can just replace one's body and download consciousness? A superior body designed to resist aging could perhaps give centuries of life. Biologically designed and grown in labs, or perhaps very advanced robotics. It eliminates many issues regarding organ repair or replacement, and allows for attacking the problems with a clean slate. The many questions are how, of course, and perhaps with a century or so of development, it's possible. Ai will surely greatly speed development.
Concerning Musk, you really have to admire his vision and entrepreneurial skills. As a human being, IMO, he's an abject failure. His DOGE PEPFAR cuts have reportedly killed1000's of mostly very poor African women and children. Values and ethics don't seem to mean much these days as long as you're incredibly successful and wealthy. The erosion of America is real, but that's another story.
Fusogen-induced recovery of spinal cord function and morphology after complete transection
This study reports the effects of a fusogen sealant, composed of polyethylene glycol and chitosan, in an experimental model of complete spinal cord transection in pigs.
Citation: Lebenstein-Gumovski M, Rasueva T, Kovalev D, Canavero S, Zharchenko A, Petrov P, et al. (2026) Fusogen-induced recovery of spinal cord function and morphology after complete transection. PLoS One 21(6): e0349579
If I understood the article correctly, it argues that rejuvenating the body (returning it to an ideal, youthful norm) is fundamentally an engineering problem. However, no one is seriously trying to solve it. Instead, researchers are merely nibbling small pieces off aging without any noticeable success in significantly increasing either average or maximum human lifespan.
In the next 25–30 years, nothing will work except for transplanting a new body — whether artificial or a young natural one — and concentrating therapies on the brain. Beyond that, it’s hard to see clearly. Our decrepit body drags us toward the grave, like a snowball that grows larger with every passing year, steadily increasing the risk of death.
Greetings. I believe that head transplantation onto an artificial body or a young natural body is the only technology capable of significantly extending human life in the next 25–30 years. I am actively involved in this topic because I want to live for millions of years. Connecting the blood vessels and attaching a second head is not a problem. Moreover, we have already learned how to reconnect the spinal cord with the restoration of neural connections and functions. For more details, see on YouTube: "Dr. Michael Lebenstein-Gumovski, Ph.D. - The Future Of Transplantation Neurosurgery". If you have any information about currently active scientific groups or projects working on the transplantation of artificial or natural bodies, please let me know at hum.d@narod.ru
Thanks for sharing this Alex. Two of the biggest takeaways for me were the relationship between chronic sleep deficit and all-cause mortality and cardiac events, and the fact that no drug out there has been shown to meaningfully adjust QALYs. Look forward to your future work.
It appears that we are not yet in touch with (or at least, not yet effectively addressing) the deepest root cause(s) of age-related decline, and too focused on downstream damage. The Whack-a-mole approach, which will be increasingly challenged as a progressively increasing number of moles pop up, is essentially doomed to incremental improvement and ultimate failure. I suspect that even massive/progressive organ replacement will suffer from this effect, as each fresh organ will suffer accelerated aging by the progressively degrading plasma constitution. I'd greatly appreciate your take on this perspective.
think bigger - whole body replacement. And some folks are working on that. Not super credible folks though
A key insight from longevity science is that lifespan and healthspan are not the same. Genetics and access to care matter, but daily behaviors such as sleep, fitness, metabolic health, and stress management remain some of the strongest modifiable predictors of long-term cognitive and physical performance. Sustainable output starts with sustainable biology.
Yep, I wrote about it here:
https://www.forever.ai/p/woke-longevity-how-the-healthspan
and here:
https://www.forever.ai/p/how-much-can-you-extend-your-life
Fantastic read. It does seem enough people are spending their lives and resources to find ways to extend lives, yet, nothing has been truly successful in my wee little purview. I will go so far as to print this out to read more diligently.
Unfortunately - nothing works and there is no magic pill. But BCI and dual-purpose therapeutics have a good chance
Alex, congrats! Great work! I'm sure Elon will read carefully your article and, possibly, you will have a new job or unlimited funds)) Good luck!
I have significant funds but I operate in a very regulated industry.
Too bad you are overlooking Musk's behavior as a charlatan and a con man.
Why repair aging bodies when you can just replace one's body and download consciousness? A superior body designed to resist aging could perhaps give centuries of life. Biologically designed and grown in labs, or perhaps very advanced robotics. It eliminates many issues regarding organ repair or replacement, and allows for attacking the problems with a clean slate. The many questions are how, of course, and perhaps with a century or so of development, it's possible. Ai will surely greatly speed development.
Concerning Musk, you really have to admire his vision and entrepreneurial skills. As a human being, IMO, he's an abject failure. His DOGE PEPFAR cuts have reportedly killed1000's of mostly very poor African women and children. Values and ethics don't seem to mean much these days as long as you're incredibly successful and wealthy. The erosion of America is real, but that's another story.
Fusogen-induced recovery of spinal cord function and morphology after complete transection
This study reports the effects of a fusogen sealant, composed of polyethylene glycol and chitosan, in an experimental model of complete spinal cord transection in pigs.
Citation: Lebenstein-Gumovski M, Rasueva T, Kovalev D, Canavero S, Zharchenko A, Petrov P, et al. (2026) Fusogen-induced recovery of spinal cord function and morphology after complete transection. PLoS One 21(6): e0349579
If I understood the article correctly, it argues that rejuvenating the body (returning it to an ideal, youthful norm) is fundamentally an engineering problem. However, no one is seriously trying to solve it. Instead, researchers are merely nibbling small pieces off aging without any noticeable success in significantly increasing either average or maximum human lifespan.
In the next 25–30 years, nothing will work except for transplanting a new body — whether artificial or a young natural one — and concentrating therapies on the brain. Beyond that, it’s hard to see clearly. Our decrepit body drags us toward the grave, like a snowball that grows larger with every passing year, steadily increasing the risk of death.
Greetings. I believe that head transplantation onto an artificial body or a young natural body is the only technology capable of significantly extending human life in the next 25–30 years. I am actively involved in this topic because I want to live for millions of years. Connecting the blood vessels and attaching a second head is not a problem. Moreover, we have already learned how to reconnect the spinal cord with the restoration of neural connections and functions. For more details, see on YouTube: "Dr. Michael Lebenstein-Gumovski, Ph.D. - The Future Of Transplantation Neurosurgery". If you have any information about currently active scientific groups or projects working on the transplantation of artificial or natural bodies, please let me know at hum.d@narod.ru
Thanks for sharing this Alex. Two of the biggest takeaways for me were the relationship between chronic sleep deficit and all-cause mortality and cardiac events, and the fact that no drug out there has been shown to meaningfully adjust QALYs. Look forward to your future work.
Interesting.
I'm working on the similar idea for some time now with many billionaires
Not only posts though - will be shooting medium and short form vids