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JaneDoeNum6's avatar

Thanks for this. You are the front lines. I have said for a long time: Political drama, regulation and uncertainty is probably the biggest barrier to radical longevity. Maybe I am wrong.

Materials costs and advanced AI labs are up there— but you and China are working on this.

And I wonder if Saudi Arabia might have a way circumventing global politics and subsidizing radical longevity. But I am not there. You are.

On the tail end of the supply chain, I wonder if Roatan, the network states in Honduras has a nice legal structure (if you can get insurance your are fine) and tax structure for a few clinics. Taxes are close to zero. Labor law is carved out. But Honduras reputation and consistency and the size of Prospera is going to limit it. But the gene therapy clinics are doing well.

You already know this and more.

Stemaid has an IRB in Baja California Mexico for growing someone’s autologous pluripotent stem cells and can make some changes with CRSPR and more. (No records of teratoma). So Mexico might have a carve out for advanced stem cells.

Walter Crompton's avatar

Interesting, Alex; both inspiring and depressing. UAE is a feudal system of absolute monarchies, with only 11% actually being citizens, and the rest virtually barred from citizenship. Obviously, the current set of leaders is making wise decisions, and that is wonderful. At the same time, it is 100% based upon the good luck of sitting upon huge oil reserves and a set of relatively liberal chieftains. Things are apparently working now, and it might seem like paradise, but is this an ethically acceptable framework? Can it last, minus infinite wealth? What if the next king of Abu Dhabi (the most powerful emirate) is a mad tyrant? One could point to Germany in the 1937 as an economic miracle - with FAR less un-earned natural resources to draw upon - and we know how that ended.

The saddest thing is that as UAE draws in amazing people like yourself, the likes of USA, EU, Japan, UK, maybe China, etc. fade into the pro-longevity background due to their bloated - and effectively murderous - bureaucracies that stymie advancement. I'm not wise enough to point the way forward, but have sufficient vision to worry about a Islamic state of emperors.

Please show me how wrong I am.

JaneDoeNum6's avatar

It’s just first principles. Look at history at how wealth and poverty is created for the breadth of society. The UAE follows this.

Historically, the highest economic growth goes to countries with percentages of government spending over GDP of about 3-13%.

A place like California might be over 50%. That doesn’t count indirect taxes like DEI, insane labor law that stifles small companies trying to grow. If you counted all if that the taxes on an entrepreneur is going to be 80% of what he takes in. California can do this because it has monopolies in tech. The Dutch curse as it’s called. But it’s an outlier like the USA after World War II where it was all the industry of the world. With the successful monopolies normal economic theories have to be thrown out.

And the UAE has avoided the Dutch curse by diversifying industry.

In the mid century, Marx predicted that capitalists would destroy any middle class mid. The reality is his predictions ended up being opposite. Low tax rates produced the greatest economic advancements and the greatest growth rates in the middle class.

Let’s look at the UAE and their immigration system:

The UAE sends out more remittances than any country but the United States, with 11 million people against 340 million. Pakistan alone gets $5.5 billion of it, a fifth of its inflows; India and the Philippines the same. Straight into households, no USAID/NGO pork to some DC or Brussels leftist that basically sits behind a desk commanding the heights of economy not understanding the people connected.

The man sending it gets employer-paid health insurance, employer-paid housing, airfare home, an end-of-service lump sum, and a state wage system that catches any boss who shorts his pay. No income tax. An American laborer gets none of that.

I talked to these men. They are poor, the work is not too bad, they live with five guys in a room (like in their countries) and they renew and they bring their cousins. Things are very predictable. It does not resemble New York Times propaganda. And it says more about your news sources than anything else.

“I wife a wife and child at home. It feeds them. I don’t have the same opportunities at home,”.

“In dubai, we still have migrants that become wealthy. This happens. It’s not going to happen to me. But life is better here.”

The thing is that The UAE is simultaneously rich. Yet someone from India can feasibly live off of $500 a month if you wanted to and feel an upgrade in lifestyle.

The test of an arrangement is whether the people inside it would take it again. They do, and their villages are rising on the proceeds. That is not just ethical. It’s ecological. It helps rebuild impoverished countries. But it protects the culture of the UAE. It’s something that needs to spread.

Tatiana's avatar

Thank you for your post, Alex. Thirty years in HC have taught me that advice and recommendations for patients should be as simple and convenient as possible, just like "My mother told." And if you start following them as early as possible, many problems can be avoided. The rest should be left to modern biotechnology.

Steven Victor's avatar

YES I could not agree with you more about the UAE. I brought Stem Cells to the UAE in 2018 and have watched it bloom. The one critical aspect about longevity I like to point out and is frequently overlooked is the brain

My wife is 61 years old and has developed frontal temporal dementia

All her organs are perfect but with our brains nothing else matters

That is why we have focused on the brain and developed the Victor Brainspan program which we are launching in October

We talk about exercise your muscles but the brain is the most important “muscle”

Yes the UAE opens its arms and mind to advancing longevity and I am proud to be part of the ecosystem here

Mahesh Trivedi's avatar

Please send the link to share your article on social media. Much appreciated. Many many thanks. Mahesh Trivedi, Sydney, Australia

Mahesh Trivedi's avatar

Longevity research with insightful details is very useful to keep healthy and fit over many decades. Thanks for your work and I will be happy to share on social media with my friends and fans and followers. Mahesh Trivedi, Sydney (Founder and Author of True Blessings, Mentor and Motivational Speaker, Strengths and Leadership Coach)

Alex Orloff's avatar

Alex, good luck! You might want to wait a while before UAE (or rather, the neighbor across the strait) will return to normality.